Over at Game-ism.com there is a pretty interesting article on GLaDOS and her physical form in the PC/360/PS3 game Portal. The article goes into depth about how GLaDOS’s structure is meant to look like a bound woman hanging upside down in a straight jacket. I really only saw a tangle of wires and steel when I fought her, but his illustration makes it very clear. In the dev commentary (which I havent gone all the way through) I guess they say that they indeed tried to use female shapes when constructing her.
Pretty cool, hunh?